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pCDCAR1 MART-1(DMF5) h(28), T (CAR-T-1-M310-2)

The vector of anti-MART-1(DMF5) chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human MART-1(DMF5). The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-MART-1(DMF5) antibody linked to CD28 signaling domains. And the vector product was designed for the treatment of metastatic melanoma.

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Details

  • Target
  • MART-1(DMF5)
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Metastatic melanoma
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-CD28
  • Discription of Signaling Cassetes
  • CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatorysignals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells(APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.

Target

  • Clone
  • Melan-A
  • Host
  • Mouse and Human
  • Target Species
  • Human
  • Gene Name
  • melan-A
  • Synonyms
  • MLANA; Melan-A; Antigen LB39-AA; Antigen SK29-AA; Melanoma Antigen Recognized By T-Cells 1; MART1; MART-1; Protein Melan-A; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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