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MSLN

This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
  • CAR Vector Products
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CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-YF056 Anti-MSLN (CBL-YF013) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBL-YF013 Humanized scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF057 Anti-MSLN (CBL-YF013) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBL-YF013 Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF017 Anti-MSLN (CBL-YF01) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBL-YF001 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF018 Anti-MSLN (CBL-YF01) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBL-YF001 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8482 Anti-MSLN (CAR-ZP32) CAR Adaptors (modCAR TagscFv-biotinylated) Human CAR-ZP32 anti-biotin-dimeric avidin-CD28/CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8501 Anti-MSLN (CAR-ZP41) CAR Adaptors (modCAR TagscFv-leucine zipper) Human CAR-ZP41 Leucine zipper-CD28/41BB/CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet

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