Human Mesothelin(296-580) CAR Detection Reagent, His Tag (FITC) (XS-0423-LX46)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Human Mesothelin(296-580) CAR Detection Reagent, His Tag (FITC) is applied for evaluating Human MSLN CAR expression, and is suitable for FC application.

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Specifications

Target
MSLN

Organism
Human

Application
Used for evaluating CAR expression

Purity
>90%

Endotoxin Level
Less than 1.0 EU per μg by the LAL method.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.

Shelf-Life
Stable as supplied until expiry date on label.

Application Notes
The optimal working dilutions should be determined by the end user.

Diseases
Neuroblastoma

Molecular Characterization
The CAR detection reagent contains AA Glu 296 - Gly 580 of Human MSLN.

Conjugation
FITC

Size
25 tests; 100 tests

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Expression
HEK293 cell

Host Species
Human

Species Reactivity
Human

Form
Lyophilized

Target

Target Introduction
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositolanchored cellsurface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Target Alternative Names
mesothelin

Entrez Gene ID
10232

UniProt ID
Q96NY8-1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.