P24

Capsid protein p24: Forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is disassembled soon after virion entry (By similarity). Host restriction factors such as TRIM5-alpha or TRIMCyp bind retroviral capsids and cause premature capsid disassembly, leading to blocks in reverse transcription. Capsid restriction by TRIM5 is one of the factors which restricts HIV-1 to the human species. Host PIN1 apparently facilitates the virion uncoating. On the other hand, interactions with PDZD8 or CYPA stabilize the capsid.

Associated Disease
  • HIV infection

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TCR-C205Z P24 HIV-1 C12C Human ~8kb Lentiviral KRWIILGLNK Non-modified HLA-B27 Inquiry

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VP-TCR-C364 HIV-1 C12C Human Lentivirus KRWIILGLNK Non-modified TCR > 10⁷ IFU/ml Inquiry
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