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Peptide ASQ

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Administration of peptides i.n. induces peripheral tolerance in Tg4 myelin basic protein-specific TCR-Tg mice. This is characterized by the generation of anergic, IL-10-secreting CD4+ T cells with regulatory function (IL-10 Treg). Myelin basic protein Ac1–9 peptide analogs, displaying a hierarchy of affinities for H-2 Au (Ac1–9[4K]<<[4A]<[4Y]), were used to investigate the mechanisms of tolerance induction, focusing on IL-10 Treg generation. Repeated i.n. administration of the highest affinity peptide, Ac1–9[4Y], provided complete protection against EAE, while i.n. Ac1–9[4A] and Ac1–9[4K] treatment resulted in only partial protection. Ac1–9[4Y] was also the most potent stimulus for IL-10 Treg generation. Although i.n. treatment with Ac1–9[4A] gave rise to IL-10-secreting CD4+ T cells, the population as a whole was also capable of secreting IFN-γ after an in vitro recall response to Ac1–9[4A] or [4Y]. In addition to IL-10 production, other facets of tolerance, namely, anergy and suppression (both in vitro and in vivo), were affinity dependent, with i.n. Ac1–9[4Y]-, [4A]- or [4K]-treated CD4+ T cells being the most, intermediate and least anergic/suppressive, respectively. These findings demonstrate that the generation of IL-10 Treg in vivo is driven by high signal strength.

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CAT Product Name Target Species TCR Clone Host Species Epitope Allele Vector Type Inquiry & Datasheet
TCR-YC0886 Mouse anti-Peptide ASQ T cell receptor ((Tg4)-1), pCDTCR1 Tg4 Mouse ASQARPSQR + ACET(A1) H-2Aᵘ Lentiviral vector   Add to Cart   Datasheet
TCR-YC0887 Mouse anti-Peptide ASQ T cell receptor ((Tg4)-2), pCDTCR1 Tg4 Mouse ASQARPSQRHG + ACET(A1) H-2Aᵘ Lentiviral vector   Add to Cart   Datasheet
TCR-YC0888 Mouse anti-Peptide ASQ T cell receptor ((Tg4)-3), pCDTCR1 Tg4 Mouse ASQYRPSQR + ACET(A1) H-2Aᵘ Lentiviral vector   Add to Cart   Datasheet
TCR-YC0889 Mouse anti-Peptide ASQ T cell receptor ((Tg4)-4), pCDTCR1 Tg4 Mouse ASQYRPSQRHG + ACET(A1) H-2Aᵘ Lentiviral vector   Add to Cart   Datasheet
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