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Anti-Peptide ASQ T cell receptor ((Tg4)-2), pCDTCR1 (TCR-YC0887)

 Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The T cell receptor (TCR) clone is specific for the NH2-terminal peptide Ac1-11[4A] of the autoantigen myelin basic protein in the context of major histocompatibility complex [MHC] class II molecule I-Aᵘ. The TCR may be used to explore the mechanism of soluble peptide therapy.

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Details

  • Target
  • Peptide ASQ
  • Epitope
  • ASQARPSQRHG + ACET(A1)
  • Format
  • Non-Modified TCR
  • Allele
  • H-2Aᵘ
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • Tg4
  • Host Species
  • Mouse

Target

  • Introduction
  • EAE has been successfully treated with the immunodominant epitope of MBP, Ac1-11, as well as analogues in which position four is changed from the native lysine to an alanine (Ac1-11[4A]) or tyrosine (Ac1-11[4Y]). Ac1-11[4A] and Ac1-11[4Y] bind to the MHC with ∼50 and 1,500 times higher affinity than does Ac1-11, and both peptides stimulate most Ac1-11–specific T cells more efficiently than does Ac1-11. The affinities of these peptides for I-Au correlate with the half-lives of each of the peptides complexed to I-Aᵘ; Ac1-11/I-Aᵘ has an immeasurably short half-life, Ac1-11[4A] has a half-life of ∼10 min, and Ac1-11[4Y]/I-Au can be detected for as long as 10 h. The efficacy of treatment of EAE with these three peptides correlates with the affinity of the peptides for I-Aᵘ. The mechanism of this treatment may be due to anergy, deletion, a switch in Th subset, or a combination of these phenomena.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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