telomerase catalytic subunit protein

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Associated Disease
  • Cancer

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-L111Z telomerase catalytic subunit protein Human Human 8kb Lentiviral VYGFVRACL Non-modified HLA-A*0201 Inquiry
TCR-L112 telomerase catalytic subunit protein Human Human 3111bp retroviral vector VYGFVRACL Non-modified TCR HLA-A*0201 Inquiry
TCR-L112Z telomerase catalytic subunit protein Human Human 8kb Lentiviral VYGFVRACL Cysteine-modified HLA-A*2402 Inquiry
TCR-L113 telomerase catalytic subunit protein Human Human 3111bp retroviral vector VYGFVRACL Cysteine-modified TCR HLA-A*2402 Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C521 Human Human Lentivirus VYGFVRACL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C522 Human Human Lentivirus VYGFVRACL Cysteine-modified TCR > 10⁷ IFU/ml Inquiry
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