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telomerase catalytic subunit protein

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Associated Disease
  • Cancer
  • TCR Vector Products
  • TCR Viral Particles
CAT Product Name Target Species Antibody Clone Antibody Host Epitope HLA Vector Type  
TCR-L112 Human anti-TERT (VYGFVRACL) T Cell Receptor, pGMT7 Human Human VYGFVRACL HLA-A*0201 retroviral vector   Inquiry
  Datasheet
TCR-L113 Human anti-TERT (VYGFVRACL) T Cell Receptor[Cysteine-modified], pGMT7 Human Human VYGFVRACL HLA-A*2402 retroviral vector   Inquiry
  Datasheet
TCR-L111Z Human anti-telomerase catalytic subunit protein (aa461-469) T cell receptor, pCDTCR1 Human Human VYGFVRACL HLA-A*0201 Lentiviral   Inquiry
  Datasheet
TCR-L112Z Human anti-telomerase catalytic subunit protein (aa461-469) T cell receptor (Cysteine-modified), pCDTCR1 Human Human VYGFVRACL HLA-A*2402 Lentiviral   Inquiry
  Datasheet

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