TIL Isolation and Expansion Service

At Creative Biolabs, we offer comprehensive Tumor-Infiltrating Lymphocyte (TIL) Isolation and Expansion Services as part of our end-to-end support for TIL therapy development. Our service focuses on the effective isolation of TILs from patient tumor samples and their expansion to therapeutic levels, ensuring a robust supply of potent, tumor-targeting lymphocytes. This process is essential for creating high-quality TIL therapies capable of providing a targeted and personalized approach to cancer treatment.

Importance of TIL Isolation and Expansion

TIL Isolation and Expansion Service at Creative Biolabs

Our TIL Isolation and Expansion Service encompasses the entire process, from initial sample handling to the ultimate expansion of TILs. We adhere to the highest standards of quality and control, ensuring that your research is supported by reliable and potent immune cells.

• Process of Our Service

Details:

• TIL Isolation: Precision and Purity

The isolation of TILs from tumor tissue is a critical step in TIL therapy development, as these lymphocytes have already demonstrated the ability to infiltrate and respond to cancer cells in vivo. Our TIL Isolation Service utilizes state-of-the-art techniques and equipment to obtain pure and viable TIL populations from diverse tumor samples, ensuring that the TILs retain their functional properties and anti-tumor potential.

• TIL Expansion: Scaling for Therapeutic Application

Once isolated, TILs must be expanded to reach the required cell numbers for therapeutic efficacy. Our TIL Expansion Service involves culturing TILs in a controlled environment, using a proprietary protocol that optimizes their growth, functionality, and specificity. TILs are stimulated in this step by cytokines, like interleukin-2 (IL-2), and other growth factors that support their survival and proliferation.

• Rapid Expansion Platform

To further increase the efficiency of TIL expansion, we employ a Rapid Expansion Platform that allows us to generate millions to billions of TILs in a matter of weeks. This involves an intensive culture method where TILs are co-cultured with feeder cells and stimulated with high doses of IL-2 and anti-CD3 antibodies. This approach results in rapid cell proliferation while maintaining the cytotoxic activity of TILs.

• Quality Control and Characterization

Throughout the isolation and expansion process, our quality control team performs rigorous tests to ensure the purity, viability, and functional integrity of the TILs. We use flow cytometry, cytokine release assays, and cytotoxicity assays to characterize the expanded TIL population, verifying their tumor-targeting capabilities. Each batch undergoes strict quality checks to confirm compliance with various standards, ensuring the TILs are safe and effective for clinical use.

• Customizable Expansion Options

Our TIL Isolation and Expansion Service is designed to be highly customizable, accommodating different tumor types and therapy goals. Whether you need to produce TILs on a large scale or in small numbers, we provide scalable expansion solutions based on your unique requirements. For research that requires genetic modifications, such as adding chimeric antigen receptors (CARs) or T-cell receptors (TCRs), we provide options to modify TILs during the expansion process to enhance their specificity and potency.

Why Choose Creative Biolabs

With Creative Biolabs' TIL Isolation and Expansion Service, you gain access to a dedicated team of immunology experts, cutting-edge cell culture facilities, and a robust infrastructure for large-scale TIL production. Our optimized protocols and rigorous quality control procedures ensure that each TIL therapy batch is of the highest quality, offering you a reliable and effective foundation for advancing your TIL therapy development.

By partnering with us, you benefit from:

Contact Us for More

Whether you are conducting research or preparing for specific trials, our TIL Isolation and Expansion Service offers a streamlined, efficient solution that enables you to develop highly potent TIL-based therapies with confidence. For more information on our TIL services or to discuss a customized solution for your program, please contact us today.

Reference

1. Kazemi, Mohammad Hossein et al. "Tumor-infiltrating lymphocytes for treatment of solid tumors: It takes two to tango?." Frontiers in immunology vol. 13 1018962. 28 Oct. Distributed under Open Access license CC BY 4.0, without modification.