The vector of anti-TR1 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human TR1. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-TR1 antibody linked to CD3ζ signaling domains. And the vector product was designed for the treatment of TR-expressing tumors.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|VP-CAR-LC811||Lenti-TR1 CAR (scFv-CD3ζ, TR404) Viral Particle|
|CAR-MZ113||Anti-TR1 (TR404) h(CD28-CD3ζ) CAR, pCDCAR1|
|CAR-MZ115||Anti-TR1 (TR404) h(CD28-CD137-CD3ζ) CAR, pCDCAR1|
|VP-CAR-LC813||Lenti-TR1 CAR (scFv-CD137-CD3ζ, TR404) Viral Particle|
|VP-CAR-LC814||Lenti-TR1 CAR (scFv-CD28-CD137-CD3ζ, TR404) Viral Particle|
|VP-CAR-LC812||Lenti-TR1 CAR (scFv-CD28-CD3ζ, TR404) Viral Particle|
|CAR-MZ242||Anti-TR1, CD8 h(CD28-CD137-CD3ζ) CAR, pCDCAR1|
|CAR-MZ114||Anti-TR1 (TR404) h(CD137-CD3ζ) CAR, pCDCAR1|
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