VivoCAR™ Anti-CD123 (32716) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX108)

Name: VivoCAR™ Anti-CD123 (32716) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX108
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD123 (32716) h(CD28-41BB-CD3z) CAR circRNA leverages the 32716 clone, specifically chosen for its ability to recognize CD123 in blastic plasmacytoid dendritic cell neoplasm (BPDCN). For in-situ cell engineering, this clone is vital for achieving rapid tumor clearance in aggressive hematologic malignancies. The circular RNA structure protects the transcript from degradation, facilitating a steady supply of CAR protein to endogenous lymphocytes. This approach offers a safe and repeatable strategy, ensuring that the patient's normal hematopoietic niche is protected from chronic genetic modification.

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Target Information

Target
CD123

Common Name
CD123

Alternative Names
IL-3R-alpha, IL3RY, IL3RX, IL3RY, hIL-3Ra, IL3RA

Full Name
Cluster of Differentiation 123

Introduction
CD123 is the α subunit of the high-affinity receptor for Interleukin-3 (IL3). It is highly and selectively overexpressed on leukemic stem cells (LSCs) in most cases of Acute Myeloid Leukemia (AML), as well as on plasmacytoid Dendritic Cells (pDCs). Its high expression on LSCs and limited expression on normal hematopoietic stem cells make it a critical target for eradicating the root of AML and preventing relapse, while minimizing severe myelosuppression.

Targeting Diseases
Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS), Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN), Chronic Myeloid Leukemia (CML)

UniProt ID
O75794

Gene ID
3563

Target Species
Human

Antibody Clone
32716

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Related Resources

Overview of CD123-Targeted CAR Cell Therapies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-CD123 (32716) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX108)

Target Information

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