VivoCAR™ Anti-CD24 (NS17) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX13)

Name: VivoCAR™ Anti-CD24 (NS17) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX13
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD24 (NS17) h(CD28-41BB-CD3z) CAR circRNA leverages the NS17 clone to provide a precision-engineered tool for in vivo targeting of cancer stem cell populations. The NS17 clone is significant for its high specificity toward CD24+ progenitor cells, making it an essential component for studies aiming to prevent tumor recurrence and metastasis. When delivered via the stable, non-viral circRNA platform, the NS17-CAR provides a controlled therapeutic window that minimizes the risk of long-term depletion of normal regenerative tissues while maximizing the destruction of aggressive, CD24-high malignant subpopulations.

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Target Information

Target
CD24

Common Name
CD24

Alternative Names
Heat Stable Antigen, Small cell lung carcinoma cluster 4, CD24A

Full Name
CD24 molecule

Introduction
CD24 is a small, highly glycosylated protein anchored to the cell membrane by a GPI linkage. It is expressed on B lymphocytes and neuronal cells, and its expression is often upregulated in various solid and hematological malignancies, where it promotes proliferation, metastasis, and acts as a "don't eat me" signal to macrophages, thus evading phagocytosis.

Targeting Diseases
B-cell malignancies (e.g., B-ALL), Solid Tumors (e.g., Ovarian, Pancreatic, Prostate Cancer)

UniProt ID
P25063

Gene ID
100133941

Target Species
Human

Antibody Clone
NS17

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-CD24 (NS17) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX13)

Target Information

Customer Reviews and Q&As

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