VivoCAR™ Anti-CD5 (7H7) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX73)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD5 (7H7) h(CD28-41BB-CD3z) CAR circRNA leverages the 7H7 clone, optimized for its rapid binding to CD5+ leukemic blasts in the bone marrow and blood. For in vivo applications, this clone is vital for achieving rapid tumor debulking in aggressive hematologic environments. The circular RNA structure protects the transcript from degradation, facilitating a steady supply of CAR protein. This provides a safe, transient, and repeatable therapeutic strategy for the research of CD5-positive malignancies, eliminating the risk of insertional mutagenesis associated with traditional gene therapy.

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Target Information

  • Target
  • CD5
  • Common Name
  • CD5
  • Alternative Names
  • LEU1, T1
  • Full Name
  • Cluster of Differentiation 5
  • Introduction
  • CD5 is a transmembrane glycoprotein expressed on mature T cells and a subset of B1 cells. Crucially, it is also highly expressed on malignant T cells, making it a potential therapeutic target for T-cell malignancies (like T-ALL and T-cell lymphomas).
  • Targeting Diseases
  • T-Cell Acute Lymphoblastic Leukemia (T-ALL), Chronic Lymphocytic Leukemia (CLL), T-cell Lymphoma
  • Target Species
  • Human
  • Antibody Clone
  • 7H7
  • scFv-Host Species
  • Mouse
  • Receptor_Construction
  • CD28-41BB-CD3z
  • Generation
  • Third
  • Description of Signaling Cassetes
  • The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.
  • Structure
  • Circula
  • Product Type
  • CAR IVT circRNA
  • Concentration
  • Lot specific
  • Storage
  • Aliquot and store at -80°C. Avoid freeze/thaw cycles.
  • Handling
  • Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.
  • IVT Vector Sequencing
  • Pass
  • IVT Vector Enzyme Digestion
  • Pass
  • Purity OD260/280
  • Pass
  • RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
  • Pass
  • RNA Sequence Assessment
  • Pass
  • Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
  • Pass
  • Endotoxin (<10 EU/mg)
  • Pass
  • In Vitro Transfection and Expression (Optional)
  • Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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