VivoCAR™ Anti-CD70 (2F2) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX77)

Name: VivoCAR™ Anti-CD70 (2F2) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX77
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD70 (2F2) h(CD28-41BB-CD3z) CAR circRNA leverages the 2F2 clone, specifically optimized for high-affinity recognition of CD70 in the tumor microenvironment. This clone is significant for its ability to trigger potent cytolytic signaling upon minimal antigen encounter, making it ideal for the in-situ engineering of effector cells against "cold" tumors. The stable circRNA scaffold provides a durable yet programmable expression window, empowering the host's immune system to purge CD70-positive malignant populations while ensuring the eventual recovery of normal activated lymphocytes once the transcript is naturally cleared.

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Target Information

Target
CD70

Common Name
CD70

Alternative Names
CD27-L, CD27L, CD27LG, LPFS3, TNFSF7, TNLG8A

Full Name
Cluster of Differentiation 70

Introduction
CD70 is the ligand for CD27 and is a member of the TNF superfamily. It is normally expressed transiently on activated T and B cells. Crucially, it is overexpressed constitutively on various hematological malignancies and solid tumors, including NHL, Renal Cell Carcinoma (RCC), and Glioblastoma (GBM). CD70 binding to CD27 delivers a costimulatory signal, and its abnormal expression promotes tumor survival and immune evasion.

Targeting Diseases
Non-Hodgkin Lymphoma (NHL), Acute Myeloid Leukemia (AML), Renal Cell Carcinoma (RCC), Glioblastoma (GBM)

UniProt ID
P32970

Gene ID
970

Target Species
Human

Antibody Clone
2F2

scFv-Host Species
Mouse

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Related Resources

Overview of CD70-Targeted CAR Cell Therapies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.