VivoCAR™ Anti-CD72 (sc02-004) h(CD28-41BB-CD3z) CAR saRNA (XS-0326-XU109)

Name: VivoCAR™ Anti-CD72 (sc02-004) h(CD28-41BB-CD3z) CAR saRNA
SKU: XS-0326-XU109
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD72 (sc02-004) h(CD28-41BB-CD3z) CAR saRNA utilizes a high-efficiency saRNA backbone to drive the sc02-004 clone. In vivo, this clone is essential for targeting the CD72 pan-B-cell marker. The saRNA platform achieves biological magnification, ensuring robust CAR expression from a sparing dose. This makes it an ideal candidate for in situ T-cell modification to target B-cell malignancies that have lost CD19 or CD20, providing a potent alternative for treating relapsed or refractory lymphoma.

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CAR Information

Target
CD72

Target Species
Human

Antibody Clone
sc02-004

scFv Host Species
Human

Receptor Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation CD28-41BB-CD3ζ architecture employs a sequential costimulatory strategy, where the CD28 module drives rapid initial activation and metabolic reprogramming, while the 4-1BB component sustains long-term cellular viability and mitigates exhaustion. This tandem design, anchored by the CD3ζ signaling chain, synergistically amplifies downstream signal transduction, resulting in a balanced T-cell phenotype with robust effector capacity and prolonged durability. The integrated signaling cascade thus optimizes both kinetic expansion and persistence, enhancing antitumor efficacy.

CAR saRNA Properties

Structure
Linear

Cap
Cap 1

PolyA
Segmented PolyA

Product Type
CAR IVT saRNA

Concentration
Lot specific

Buffer
1 mM Sodium Citrate, pH 6.4 (or specialized RNA storage buffer, RNase-free).

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

saRNA Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Target Information

Full Name
Cluster of Differentiation 72

Alternative Names
CD72b; LYB2

Introduction
CD72 is a type II transmembrane protein expressed on B cells from the pro-B to the mature B-cell stage. It acts as a negative regulator of BCR signaling and is a reliable marker for B-lineage malignancies.

Targeting Diseases
B-cell Acute Lymphoblastic Leukemia (B-ALL), Chronic Lymphocytic Leukemia (CLL), Mantle Cell Lymphoma (MCL)

UniProt ID
P21854

Gene ID
971

Case Studies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.