Name: VivoCAR™ Anti-ERBB2 (F5) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX35
Rating: 5 (1 reviews)

Solutions
- Solutions
  Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
  EXPLORE MORE Highlights
  - TCR-T Development Solutions
  - CAR-T Development Solutions
Products
- Products
  We focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
  EXPLORE MORE Highlights
  - CAR/TCR Development Kits
  - Oncology
CDMO
- CDMO
  The advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
  EXPLORE MORE
Platforms
- Platforms
  To accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
  EXPLORE MORE Highlights
  - CAR Technology
  - TCR Technology
Resources
- Resources
  Use the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
  EXPLORE MORE Highlights
  - Flyers
  - Newsletter
Company
- - Distributors
  - About Us
  - Contact Us
  - Careers
  - Events
- About Creative Biolabs
  Get a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
  EXPLORE MORE

Product Search Services Search Keyword Search

Target Information

Target
ERBB2

Common Name
ERBB2

Alternative Names
NEU, NGL, HER2, TKR1, CD340, HER-2, VSCN2, MLN 19, MLN-19, c-ERB2, c-ERB-2, HER-2/neu, p185(erbB2)

Full Name
erb-b2 Receptor Tyrosine Kinase 2

Introduction
ERBB2 is a member of the ErbB family of receptor tyrosine kinases. It is highly activated in many aggressive cancers due to gene amplification and overexpression, particularly in breast and gastric tumors. Its lack of a known ligand and its role as a preferred dimerization partner for other ErbB receptors make it a critical oncogenic driver and a premier therapeutic target.

Targeting Diseases
Breast Cancer, Gastric Cancer, Ovarian Cancer, Lung Cancer

UniProt ID
P04626

Gene ID
2064

Target Species
Human

Antibody Clone
F5

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Customer Reviews and Q&As

There are currently no customer reviews or questions for VivoCAR™ Anti-ERBB2 (F5) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX35). Click the button below to contact us or submit your feedback about this product.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.