VivoCAR™ Anti-FRα (huMov19) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX116)

Name: VivoCAR™ Anti-FRα (huMov19) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX116
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-FRα (huMov19) h(CD28-41BB-CD3z) CAR circRNA features the clinically validated huMov19 clone, humanized to maximize stability and minimize host anti-drug antibodies during in-situ cell engineering. This formulation is significant for its ability to maintain high binding efficiency in the acidic environment of large solid tumor masses. The circular RNA scaffold ensures robust CAR translation, empowering host lymphocytes to penetrate and destroy FRα-positive clusters. Its transient nature provides a controllable therapeutic pulse, ensuring that the immune system returns to homeostasis after the clearance of metastatic lesions.

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Target Information

Target
FRα

Common Name
FOLR1

Alternative Names
FBP, FOLR, FRalpha, NCFTD, FOLR1

Full Name
Folate Receptor Alpha

Introduction
FRα is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that binds folic acid with high affinity. While expression in normal tissues is restricted to the apical surface of some epithelia (e.g., kidney, lung), it is highly overexpressed in many epithelial cancers, particularly non-mucinous ovarian carcinomas. Its high tumor-to-normal tissue ratio and role in cell signaling make it a premier target for both antibody-drug conjugates (ADCs) and CAR-T therapies.

Targeting Diseases
Ovarian Cancer, Endometrial Cancer, Non-Small Cell Lung Cancer (NSCLC), Breast Cancer (Triple-Negative)

UniProt ID
P15328

Gene ID
2348

Target Species
Human

Antibody Clone
huMov19

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.