Close

A ZipCAR [BZip-28ζ], with a CAR Adaptor [Anti-MUC1 Antibody scFv(Pemtumomab)-AZip], a SUPRA CAR System (CAR-NR-ZP655)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The split, universal, and programmable (SUPRA) CAR system is a two-component receptor system consisting of a universal receptor with leucine zipper adaptor (zipCAR) on T cells and a separate scFv with leucine zipper adaptor (zipFv) molecule targeting specific antigens. This split "lock-key" structure of SUPRA CAR with leucine zipper adaptors was desighed to enhance the flexibility and controllability of CARs, which has several clinically relevant advantages over a rigid CAR system:

• Antigen targets of one set of zipCAR T cells can be switched, expanded and combined without further modification of the CAR T cells.
• The activities and toxicities of SUPRA CAR T cells can be controlled and fine-tuned.
• Signaling domains and effector cell types can be changed and combined.

Creative Biolabs provides customized SUPRA design and construction services. Please contact us for more detailed information.

Specific Inquiry

  • Size:
  • Marker:
  • Form:
  Add to Cart

CAR Schemeitc

UniCAR

  • CAR Construction
  • BZip-CD28-CD3ζ
  • Discription of Signaling Cassetes
  • CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide costimulatory signals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells (APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and CD28. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
  • Vector Name
  • pCDCAR1
  • Vector length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Targeting Diseases
  • Colorectal cancer

CAR Adaptor

  • Adaptor Target
  • MUC1
  • Common Name
  • MUC1
  • Adaptor Type
  • ScFv Antibody
  • Antibody Host
  • Mouse
  • Antibody Clone
  • Pemtumomab
  • CAR Adaptor Tag
  • AZip

Customize Your CAR Products

Cannot find the desired product? Don't worry, just try our online CAR and CAR cell customizing system, which offers full options to meet all unique needs, including but not limited to conventional or unconventional CAR constructs, as well as a variety of vectors and cells. The customization process can be completed with just a few simple clicks, please feel free to try it out.
CAR and CAR Cell Customizing System

Customer Reviews and Q&As

There are currently no customer reviews or questions for A ZipCAR [BZip-CD28-CD3ζ], with a CAR Adaptor [Anti-MUC1 Antibody scFv(Pemtumomab)-AZip], a SUPRA CAR System (CAR-NR-ZP655). Click the button below to contact us or submit your feedback about this product.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Online Inquiry

For any technical issues or product/service related questions, please leave your information below. Our team will contact you soon.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Key Updates
Newsletter NEWSLETTER

The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders

LEARN MORE NEWSLETTER
New Solution NEW SOLUTION

CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.

LEARN MORE SOLUTION
NOVEL SOLUTION NOVEL TECHNOLOGY

Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.

LEARN MORE NOVEL TECHNOLOGY
NEW TECHNOLOGY NEW SOLUTION

Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.

LEARN MORE SOLUTION
Receive our latest news and insights.