All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The vector of anti-CD30 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human CD30. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD30 antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Hodgkin lymphomas.
CAR Construction : T105 scFv-41BB-CD28ζ Fig.1 Flow cytometry. Representative plot of T cells transduced at day 2 with CD30-CAR-encoding lentivirus and CD30-CAR expression and analysed by flow cytometry using an anti-CD3 and anti-EGFRt antibodies. Alvarez-Fernández, C., Escribà-Garcia, L., Caballero, A. C., Escudero-López, E., Ujaldón-Miró, C., Montserrat-Torres, R., Pujol-Fernández, P., Sierra, J., & Briones, J. (2021). Memory stem T cells modified with a redesigned CD30-chimeric antigen receptor show an enhanced antitumor effect in Hodgkin lymphoma. Clinical & translational immunology, 10(4), e1268. |
CAR Construction : T105 scFv-41BB-CD28ζ Fig.1 CD30-CAR TSCM-like enriched culture efficiently eradicates HL in vitro. Cytokine secretion of CD30-CAR TSCM-like enriched culture (n = 3) 24 h after L540, L428 and Raji co-culture. Untransduced TSCM-like cells were used as negative control. Cytokine levels of IL-2, IL-6, IL-10, IFN-γ and TNF-α were measured by cytometry-based multiplex analysis (mean ± SD). Alvarez-Fernández, C., Escribà-Garcia, L., Caballero, A. C., Escudero-López, E., Ujaldón-Miró, C., Montserrat-Torres, R., Pujol-Fernández, P., Sierra, J., & Briones, J. (2021). Memory stem T cells modified with a redesigned CD30-chimeric antigen receptor show an enhanced antitumor effect in Hodgkin lymphoma. Clinical & translational immunology, 10(4), e1268. |
More Published Data More Published Data
There are currently no customer reviews or questions for Anti-CD30 (T105) h(CD28-CD3ζ) CAR, pCDCAR1 (CAR-ZP2616). Click the button below to contact us or submit your feedback about this product.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
For any technical issues or product/service related questions, please leave your information below. Our team will contact you soon.
The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders
LEARN MORE NEWSLETTERCellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
LEARN MORE SOLUTIONSilence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
LEARN MORE NOVEL TECHNOLOGYCanine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
LEARN MORE SOLUTION