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anti-CEACAM5 (aa691-699) TCR, pCDTCR1 (TCR-L010Z)

The vector of anti-CEACAM5 T cell receptor (TCR) is constructed for the engineering of T cell to target Human CEACAM5. The T cells are genetically modified through transduction with a retroviral vector expressing CEACAM5-specific T cell receptor. And the vector product was designed for the treatment of Colorectal cancer.

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Details

  • Target
  • CEACAM5
  • Target Species
  • Human
  • Epitope
  • IMIGVLVGV
  • Format
  • Codon optimized
  • HLA
  • HLA-A2
  • Targeting Diseases
  • Colorectal cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Antibody Host
  • Mouse

Target

  • Official Symbol
  • CEACAM5
  • Introduction
  • This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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