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Anti-CMV (KEVNSQLSL) TCR, pCDTCR1 (TCR-L011Z)

The vector of anti-CMV T cell receptor (TCR) is constructed for the engineering of T cell to target CMV. The T cells are genetically modified through transduction with a retroviral vector expressing CMV-specific T cell receptor. And the vector product was designed for the treatment of cytomegalovirus infection.

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Details

  • Target
  • CMV
  • Target Species
  • CMV
  • Epitope
  • KEVNSQLSL
  • Format
  • Cysteine-modified TCR
  • HLA
  • HLA-B4001
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Viral Infection
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Host Animal
  • Human

Target

  • Introduction
  • Cytomegalovirus (CMV) is a virus in the family Herpesviridae. Humans and monkeys are natural hosts. There are currently eight species of this genus, including human beta herpesvirus type 5 (HCMV, human cytomegalovirus, HHV-5), which is a human-infected species. Diseases associated with HHV-5 include mononucleosis and pneumonia. Human cytomegalovirus is the most studied of all cytomegaloviruses.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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