VivoCAR™ Anti-GD2 (huKM666) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX21)

Name: VivoCAR™ Anti-GD2 (huKM666) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX21
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-GD2 (huKM666) h(CD28-41BB-CD3z) CAR circRNA represents the humanized evolution of GD2-targeted therapy, specifically optimized for repeated in vivo dosing cycles. The importance of the huKM666 clone lies in its minimized immunogenicity, which prevents host-mediated neutralization and ensures the longevity of the circRNA-mediated CAR response across multiple LNP administrations. This product excels in clinical research settings where safe, iterative immune stimulation is required to achieve complete remission in GD2-positive malignancies, providing a sophisticated tool for sustainable and non-integrating cell therapy.

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Target Information

Target
GD2

Common Name
GD2

Alternative Names
Disialoganglioside GD2

Full Name
Disialoganglioside GD2

Introduction
GD2 is a disialoganglioside highly expressed on the surface of neuroectoderm-derived tumors, notably Neuroblastoma, Glioblastoma, and Melanoma, with very limited expression on normal tissues (primarily peripheral nerves). It is a well-validated target for CAR-T cell therapy against solid tumors.

Targeting Diseases
Neuroblastoma, Glioblastoma (GBM), Melanoma, Osteosarcoma

UniProt ID
N/A (Lipid-based antigen)

Gene ID
N/A

Target Species
Human

Antibody Clone
huKM666

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-GD2 (huKM666) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX21)

Target Information

Customer Reviews and Q&As

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