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Anti-HDV TCR, pMSGV1 (TCR-L048)

The vector of anti-HDV T cell receptor (TCR) is constructed for the engineering of T cell to target HDV. The T cells are genetically modified through transduction with a retroviral vector expressing HDV-specific T cell receptor. And the vector product was designed for the treatment of HDV infection.

Details

  • Target
  • HDV
  • Target Species
  • HDV
  • Format
  • Non-modified TCR
  • HLA
  • HLA-A2
  • Targeting Diseases
  • HDV infection
  • Vector Name
  • pMSGV1
  • Vector Length
  • 6700-8070bp
  • Vector Type
  • retroviral vector
  • Antibody Host
  • Human

Target

  • Gene Name
  • Hepatitis D Virus
  • Official Symbol
  • HDV
  • Synonyms
  • LYZC; LYZ; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Immunodeficiency diseases
  • Introduction
  • The hepatitis delta virus (HDV) is distributed worldwide and related to the most severe form of viral hepatitis. HDV is a satellite RNA virus dependent on hepatitis B surface antigens to assemble its envelope and thus form new virions and propagate infection. HDV has a small 1.7 Kb genome making it the smallest known human virus. This deceivingly simple virus has unique biological features and many aspects of its life cycle remain elusive. The present review endeavors to gather the available information on HDV epidemiology and clinical features as well as HDV biology.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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