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Anti-ITGB3 T cell receptor (D48T12), pCDTCR1 (TCR-YC0583)

Clone D48T12, was activated to secrete cytokines (Figure 5; only data for D48T12 are shown). This activation was antigen specific, since no activation was detected with even the highest peptide pulse concentration (15 μM) of LolP1.

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Details

  • Target
  • ITGB3
  • Target Species
  • Human
  • Epitope
  • AWCSDEALPPGS
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-DRB3*01:01
  • Targeting Diseases
  • Fetal and neonatal alloimmune thrombocytopenia (FNAIT)
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • D48T12
  • Host Species
  • Human

Target

  • Introduction
  • The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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