ITGB3

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. The ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cell fragments called platelets. Platelets circulate in blood and are an essential component of blood clots. The beta3 subunit attaches (binds) to the alphaIIb subunit, which is produced from the ITGA2B gene, to form integrin αIIbβ3. It is estimated that 80,000 to 100,000 copies of integrin αIIbβ3 are present on the surface of each platelet. During clot formation, integrin αIIbβ3 binds to a protein called fibrinogen. Attachment of integrin αIIbβ3 from adjacent platelets to the same fibrinogen protein helps platelets cluster together (platelet cohesion) to form a blood clot. Blood clots protect the body after injury by sealing off damaged blood vessels and preventing further blood loss. Integrin αIIbβ3 can also bind other proteins on platelets and in the blood as well as proteins within the intricate lattice that forms in the space between cells (extracellular matrix) to ensure proper clot formation and promote wound healing.

Associated Disease
  • Chronic lymphocyticleukemia (CLL)

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-T-1-L339-2 T cell First PM6/13 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-L339-G T cell First PM6/13 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-L339-Z T cell First PM6/13 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-L339-2G T cell Second PM6/13 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-L339-2Z T cell Second PM6/13 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-L339-4G T cell Second PM6/13 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-L339-4Z T cell Second PM6/13 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-L339-8Z T cell Second PM6/13 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-L339-BZ T cell Second PM6/13 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-L339-CZ T cell Second PM6/13 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-L339-2BZ T cell Third PM6/13 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-L339-2XZ T cell Third PM6/13 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC293 PM6/13 Lentivirus First scFv (PM6/13)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC294 PM6/13 Lentivirus First scFv (PM6/13)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC295 PM6/13 Lentivirus First scFv (PM6/13)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC296 PM6/13 Lentivirus Second scFv (PM6/13)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC297 PM6/13 Lentivirus Second scFv (PM6/13)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC298 PM6/13 Lentivirus Second scFv (PM6/13)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC299 PM6/13 Lentivirus Second scFv (PM6/13)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC300 PM6/13 Lentivirus Second scFv (PM6/13)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC301 PM6/13 Lentivirus Second scFv (PM6/13)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC302 PM6/13 Lentivirus Second scFv (PM6/13)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC303 PM6/13 Lentivirus Third scFv (PM6/13)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC304 PM6/13 Lentivirus Third scFv (PM6/13)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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