TCR-like monoclonal antibodies (TCR-like mAbs), which recognise a specific peptide in association with an MHC molecule (human leukocyte antigen, HLA in humans), permit the targeting of such inaccessible nuclear or cytoplasmic tumor- or virus-associated antigens based on binding to their MHC-presented peptides found on the surface of target cells. Since they allow, for the first time, visualization of MHC/peptide complexes on various cells in health and disease, they belong to a new class of antibodies which can be utilized as important tools in molecular immunology.
Creative Biolabs has been raised against peptides from many of such antigens. This TCR-like antibody specifically targets to HumanMAGE3 antigen that recognizes epitope FLWGPRALV presented on HLA-A*0201. This product is mainly used to treat Melanoma.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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