The anti-MUC1 TriCAR is a novel chimeric antigen receptor (CAR) constructed for the engineering of T cells to target Human MUC1.More specifically, the TriCAR is a CAR-T with unique TriTE (Tri-functional T cell Engager) construct. In general, TriTE is a fusion protein with unique functions including T cell engagement, T cell stimulation, and check point blocking. It consists of five components, including R1(antigen binding domain), R2 (anti-CD3, here refer to the CD28/4-1BB-CD3ζ intracellular constimulatory domain), R3 & R4(IL15 binding domain), and R5 (PD1 for binding to PD-L1). Therefore, the TriCAR contains an anti-antigen scFv, a PD-L1 blocker, and a cytokine complex, enabling the TriCAR/SILK to simultaneously targeting the antigen-specific cancer cells, blocking the inhibitory PD-L1 signal and stimulating innate T/NK cell activation and expansion, thus make it a tri-functional CAR (Tri-CAR).
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