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Anti-MUC1 TriCAR (Clivatuzumab) (28ζ), pCDCAR1 (TriCAR-Z275)

The anti-MUC1 TriCAR is a novel chimeric antigen receptor (CAR) constructed for the engineering of T cells to target Human MUC1.More specifically, the TriCAR is a CAR-T with unique TriTE (Tri-functional T cell Engager) construct. In general, TriTE is a fusion protein with unique functions including T cell engagement, T cell stimulation, and check point blocking. It consists of five components, including R1(antigen binding domain), R2 (anti-CD3, here refer to the CD28/4-1BB-CD3ζ intracellular constimulatory domain), R3 & R4(IL15 binding domain), and R5 (PD1 for binding to PD-L1). Therefore, the TriCAR contains an anti-antigen scFv, a PD-L1 blocker, and a cytokine complex, enabling the TriCAR/SILK to simultaneously targeting the antigen-specific cancer cells, blocking the inhibitory PD-L1 signal and stimulating innate T/NK cell activation and expansion, thus make it a tri-functional CAR (Tri-CAR).

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Details

  • Target
  • MUC1
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Colorectal cancer
  • Generation
  • Fourth
  • Vector Name
  • pCDCAR1
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • scFv-Sushi Domain-CD28-CD3ζ-PP2A-IL15-Anti-PD-L1
  • Discription of Signaling Cassetes
  • TriCAR is a CAR-T with unique TriTE (Tri-functional T cell Engager) construct. TriTE is a fusion protein with unique functions including T cell engagement, T cell stimulation, and check point blocking. It consists of five components, including R1(antigen binding domain), R2 (CD28/4-1BB-CD3ζ intracellular constimulatory domain), R3 & R4(IL15 binding domain), and R5 (PD1 for binding to PD-L1). The R1 component binds to a specific cancer antigen on T cells , and and at the same time, the IL15 and PD1 (R4&R5) domains improve the in-tumor micro-environment for solid tumor immunotherapies.

Target

  • Clone
  • Clivatuzumab
  • Target Species
  • Human
  • Gene Name
  • Mucin 1
  • Synonyms
  • Mucin 1; MUC1; CD227; EMA; H23AG; KL-6; MAM6; MUC-1/SEC; MUC-1/X; MUC1/ZD; PEM; PEMT; PUM; CA 15-3; Episialin

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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