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Anti-OCH T cell receptor (Vβ8.2), pCDTCR1 (TCR-YC0773)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-OCH T cell receptor (TCR) is constructed for the engineering of T cell to target OCH restricted by mouse CD1d. The T cells are genetically modified through transduction with a lentiviral vector expressing OCH-specific T cell receptor.

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Details

  • Target
  • OCH
  • Epitope
  • OCH
  • Format
  • Non-Modified TCR
  • Allele
  • mouse CD1d
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • Vβ8.2
  • Host Species
  • Mouse

Target

  • Introduction
  • α-GalCer, also known as KRN7000, is the prototypical agonist for NKT cells that possesses an 18C phytosphingosine and a 26C acyl chain. Because many analogs of this Ag have been generated that promote distinct NKT cell responses, a critical question is whether the altered functionality is determined by their differential impact on TCR binding. A panel of 10 different AGLs had been investigated: (1) α-GalCer, (2) OCH, with C9 phytosphingosine and C24:0 acyl chains; (3) C20:2, a C20 acyl chain and cis-diunsaturation at C11 and 14; (4) α-GlcCer, identical ceramide component to C20:2, but α-linked glucosyl head group; (5) 3′,4″-deoxy-α-GalCer, both the 3′-OH of the sugar and the 4′-OH of the sphingoid base are removed; (6) 4′,4″-deoxy-α-GalCer, both the 4′-OH of the sugar and the 4′-OH of the sphingoid base are removed; (7) 4′-deoxy-α-GalCer, with a 4′-deoxy-sugar but retaining the 4′-OH group on the sphingoid base; (8) the 4″-deoxy-α-GalCer AGL, with an α-Gal sugar, but lacking the 4′-OH on the sphingoid base; (9) α-GalCer (C24) and (10) α-GlcCer (C24), both with 24C acyl and 18C sphingosine chains.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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