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Anti-PG T cell receptor (BC8B), pCDTCR1 (TCR-YC0976)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-PG T cell receptor (TCR) is constructed for the engineering of T cell to target Phosphatidylglycerol restricted by human CD1b. The T cells are genetically modified through transduction with a lentiviral vector expressing PG-specific T cell receptor.

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Details

  • Target
  • PG
  • Epitope
  • Phosphatidylglycerol
  • Format
  • Non-Modified TCR
  • Allele
  • human CD1b
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • BC8B
  • Host Species
  • Human

Target

  • Introduction
  • Phosphatidylglycerol is a glycerophospholipid found in pulmonary surfactant. The general structure of phosphatidylglycerol consists of a L-glycerol 3-phosphate backbone ester-bonded to either saturated or unsaturated fatty acids on carbons 1 and 2. The head group substituent glycerol is bonded through a phosphomonoester. It is the precursor of surfactant and its presence (> 0.3) in the amniotic fluid of the newborn indicates fetal lung maturity. Approximately 98% of alveolar wall surface area is due to the presence of type I cells, with type II cells producing pulmonary surfactant covering around 2% of the alveolar walls. Once surfactant is secreted by the type II cells, it must be spread over the remaining type I cellular surface area. Phosphatidylglycerol is thought to be important in spreading of surfactant over the Type I cellular surface area. The major surfactant deficiency in premature infants relates to the lack of phosphatidylglycerol, even though it comprises less than 5% of pulmonary surfactant phospholipids. It is synthesized by head group exchange of a phosphatidylcholine enriched phospholipid using the enzyme phospholipase D.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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