Artificial T Cell-Stimulating Matrix (aTM) based T Cell-Stimulating Platform Development Service

Extracellular Matrix is Important for T Cell Activation and Expansion

T cell therapies often require extensive ex vivo expansion, which can lead to T cell exhaustion and reduced therapeutic efficacy. While current synthetic T cell stimulation platforms offer efficient enrichment and activation, they lack the environmental cues found in lymphoid organs. An Artificial T Cell-Stimulating Matrix (aTM) is a biomimetic material designed to mimic this natural environment, addressing the shortcomings of ex vivo T cell activation and showing great potential in advancing cancer immunotherapy.

Fig.1 Interactions between T cells and extracellular matrix (ECM).¹

Our Artificial T Cell-Stimulating Matrix (aTM) based T Cell-Stimulating Platform Development Service

Creative Biolabs provides a cost-effective aTM based artificial T cell-stimulating platform development service to advance cancer immunotherapy development. Our innovative aTM solution utilizes cross-linking materials between different hydrogels to load T cell-stimulating signals, enabling effective stimulation and activation of T cells in situ. We collaborate with clients to customize the aTM according to their specific requirements, including the selection of suitable hydrogels, ligands, costimulatory molecules, and cytokines. Our seasoned experts meticulously adjust the concentrations and physical properties of these components to optimize T cell activation.

Additionally, we offer thorough characterization services to ensure the aTM and aTM-based artificial T cell-stimulating platform function as intended and also support large-scale research endeavors for our clients in the field of cancer immunotherapy. At Creative Biolabs, we are committed to achieving exceptional outcomes tailored to our clients' timelines, empowering them to create more effective and long-lasting cancer T cell therapies.

Attractive Features

• Customizable aTM design to precisely match your target T cell population and desired activation profile.
• Optimized microenvironment mimicry to promote physiological T cell activation, expansion, and differentiation.
• Versatile platform integration to facilitate seamless workflow integration and data acquisition.
• Scalable manufacturing capabilities to support your research needs, ranging from small-scale studies to extensive clinical uses.
• Rigorous quality control to ensure consistency, reproducibility, and sterility.
• Expert assistance and support are provided throughout the development process, from initial concept to final platform implementation.

Associated Services

In addition to aTM, we are also able to customize other hydrogel-based materials, such as aLN and immunomodulatory macroporous scaffolds, to generate better T cell stimulation platforms adapted to clients' needs. Our expertise in biomaterial design and T cell biology allows us to create bespoke platforms that mimic specific lymphoid microenvironments, ultimately enhancing the efficacy and translatability of T cell-based therapies.

• Artificial Lymph Node (aLN) Matrix based T Cell-Stimulating Platform Development Service
• Immunomodulatory Macroporous Scaffold based Artificial T Cell-Stimulating Platform Development Service

Creative Biolabs, a leading expert in T cell therapy optimization, possesses extensive theoretical knowledge and practical experience in developing advanced T cell stimulation platforms. We specialize in designing and engineering custom aTM-based solutions tailored to meet your unique research goals. Contact us now to discuss your unique needs and learn how our experience can assist you in developing a superior aTM platform for artificial T cell activation.

Reference

1. Lv, Die, et al. "Crosstalk between T lymphocyte and extracellular matrix in tumor microenvironment." Frontiers in Immunology 15 (2024): 1340702. Distributed under Open Access License CC BY 4.0, without modification.