CellRapeutics™ CD19⁺ B Cells from Multiple Sclerosis Donor (XS-0426-XU4)

Name: CellRapeutics™ CD19+ B Cells from Multiple Sclerosis Donor
SKU: XS-0426-XU4
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product contains CD19⁺ B cells obtained from donors diagnosed with Multiple Sclerosis (MS). By utilizing gentle immunomagnetic isolation techniques, the cells maintain their physiological relevance for studies involving neuroinflammation, antigen presentation to T cells in the central nervous system, and the evaluation of B cell-depleting therapeutic agents.

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Donor Information

Product Name
CellRapeutics™ CD19⁺ B Cells from Multiple Sclerosis Donor

Cat. No.
XS-0426-XU4

Donor Age
Young Adult, Middle-Aged

Donor Health
Diagnosed with Multiple Sclerosis, including relapsing-remitting or progressive subtypes. Donors demonstrate neuroinflammatory signatures and potential alterations in peripheral B-cell activation markers.

Ethnicity
Diverse backgrounds available, predominantly Caucasian.

Anticoagulant
Acid Citrate Dextrose, optimized to minimize calcium-dependent B-cell activation, ensuring the captured cells reflect their in vivo autoimmune resting or memory state.

Additional Donor Information
Each lot features CD19⁺ B cells from donors diagnosed with Multiple Sclerosis. Information includes clinical subtype, Expanded Disability Status Scale scores, and history of disease-modifying therapies, crucial for studying B-cell involvement in neuroinflammation.

Clinical Profile
Clinical subtype, Kurtzke Expanded Disability Status Scale score, time since last relapse, and history of disease-modifying therapies.

Additional Information

Medication History
Available upon request. Includes detailed records of Disease-Modifying Therapies, specifically B-cell depleting agents, interferon-beta, or S1P receptor modulators.

Formulation
Cryopreserved in specialized freezing medium

Cell Purity
>90%

Cell Viability
>90%

Mycoplasma Testing
Negative

Sterility Testing
Negative

Genetic Stability Testing
The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.

Application
Drug Discovery, Immuno-oncology Research

Research Use Only
RUO

Quality Control
Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.

Storage
Upon arrival, immediately transfer the vial to the liquid nitrogen.

Shiping
Dry Ice

Handling Notes
Upon thawing, it is recommended to rapidly thaw the cells in a 37°C water bath, followed by the slow addition of pre-warmed culture medium to minimize osmotic shock.

Warnings
Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.

Size
1E7 cells/vial, 2.5E7 cells/vial

Keywords
CellRapeutics™ CD19⁺ B Cells from Multiple Sclerosis Donor, CD19⁺ B Cells, Multiple Sclerosis

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.