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CellRapeutics™ CD19+ B Cells from Systemic Lupus Erythematosus Donor (XS-0426-XU11)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Harvested from SLE donors, these B cells are characterized by their profound dysregulation and contribution to systemic autoimmunity. This product is ideal for investigating the molecular basis of autoantibody production against nuclear antigens and the hypersensitivity of B cell receptor signaling pathways that lead to multi-organ damage.

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Donor Information

  • Product Name
  • CellRapeutics™ CD19+ B Cells from Systemic Lupus Erythematosus Donor
  • Cat. No.
  • XS-0426-XU11
  • Donor Age
  • Young Adult, Middle-Aged
  • Donor Health
  • Clinically diagnosed with Systemic Lupus Erythematosus. Donors exhibit multi-systemic autoimmune activity and significant abnormalities in B-cell tolerance and autoantibody production.
  • Ethnicity
  • Mainly African American, Hispanic, and Asian backgrounds
  • Anticoagulant
  • Heparin or Acid Citrate Dextrose, specialized to prevent clotting triggered by circulating immune complexes and anti-phospholipid antibodies, ensuring the purity of CD19+ subpopulations.
  • Additional Donor Information
  • Each lot features CD19+ B cells from donors with clinically diagnosed SLE. Detailed profiles include ANA titers, anti-dsDNA levels, and Systemic Lupus Erythematosus Disease Activity Index scores, supporting research into B-cell subsets and systemic loss of tolerance.
  • Clinical Profile
  • SLEDAI score, ACR classification criteria fulfilled, autoantibody profile, and history of organ-threatening manifestations.

Additional Information

  • Medication History
  • Available upon request. Comprehensive documentation of antimalarials, corticosteroids, and potent immunosuppressants or biologics that may impact B-cell subsets.
  • Formulation
  • Cryopreserved in specialized freezing medium
  • Cell Purity
  • >90%
  • Cell Viability
  • >90%
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • Negative
  • Genetic Stability Testing
  • The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.
  • Application
  • Drug Discovery, Immuno-oncology Research
  • Research Use Only
  • RUO
  • Quality Control
  • Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.
  • Storage
  • Upon arrival, immediately transfer the vial to the liquid nitrogen.
  • Shiping
  • Dry Ice
  • Handling Notes
  • Upon thawing, it is recommended to rapidly thaw the cells in a 37°C water bath, followed by the slow addition of pre-warmed culture medium to minimize osmotic shock.
  • Warnings
  • Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.
  • Size
  • 1E7 cells/vial, 2.5E7 cells/vial
  • Keywords
  • CellRapeutics™ CD19+ B Cells from Systemic Lupus Erythematosus Donor, CD19+ B Cells, Systemic Lupus Erythematosus

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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