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CellRapeutics™ CD3+ T Cells from Rheumatoid Arthritis Donor (XS-0426-XU218)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product consists of CD3+ T lymphocytes purified from the peripheral blood of donors meeting the clinical criteria for Rheumatoid Arthritis. These cells reflect the systemic inflammatory state of the donor, often exhibiting polarized cytokine production and markers of chronic stimulation. They are ideal for investigating the role of T-helper subsets in synovial joint destruction and evaluating the impact of small-molecule inhibitors or biologics on autoimmune T-cell signaling.

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Donor Information

  • Product Name
  • CellRapeutics™ CD3+ T Cells from Rheumatoid Arthritis Donor
  • Cat. No.
  • XS-0426-XU218
  • Donor Age
  • Middle-Aged
  • Donor Health
  • T cells exhibit signatures of chronic synovial inflammation and an expanded population of pro-inflammatory effector memory cells involved in systemic musculoskeletal autoimmunity.
  • Ethnicity
  • Diverse backgrounds available, predominantly Caucasian and East Asian cohorts.
  • Anticoagulant
  • Heparin or Acid Citrate Dextrose, utilized to mitigate the impact of high plasma viscosity and circulating rheumatoid factors, ensuring unhindered antibody-mediated magnetic separation of T cells.
  • Additional Donor Information
  • Each lot features CD3+ T cells from donors with RA. Profiles include RF and anti-CCP antibody status alongside DAS28 scores to correlate T-cell exhaustion with disease activity.
  • Clinical Profile
  • Disease duration, RF/Anti-CCP serostatus, and history of DMARDs or TNF inhibitors.

Additional Information

  • Medication History
  • Available upon request. Records of DMARDs and biological therapies targeting T-cell co-stimulation or cytokine receptors.
  • Formulation
  • Cryopreserved in specialized freezing medium
  • Cell Purity
  • >90%
  • Cell Viability
  • >90%
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • Negative
  • Genetic Stability Testing
  • The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.
  • Application
  • Drug Discovery, Immuno-oncology Research
  • Research Use Only
  • RUO
  • Quality Control
  • Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.
  • Storage
  • Store in liquid nitrogen vapor phase for long-term stability, maintain constant temperatures below -150°C to prevent loss of viability.
  • Shiping
  • Dry Ice
  • Handling Notes
  • Perform rapid thawing in a 37°C water bath and dilute slowly with pre-warmed media to ensure optimal cell recovery and function.
  • Warnings
  • Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.
  • Size
  • 2.5E7 cells/vial, 5E7 cells/vial
  • Keywords
  • CellRapeutics™ CD3+ T Cells from Rheumatoid Arthritis Donor, CD3+ T Cells, Rheumatoid Arthritis

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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