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CellRapeutics™ CD3+ T Cells from Type 1 Diabetes Donor (XS-0426-XU222)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Sourced from donors with Type 1 Diabetes Mellitus (T1DM), these CD3+ T cells include the autoreactive clones responsible for the selective destruction of pancreatic beta cells. The isolation ensures the preservation of the phenotypic identity of these cells, facilitating the study of islet-specific T-cell receptors and the metabolic requirements of autoimmune effectors. This product is prioritized for researchers developing cell-based therapies or immunomodulatory interventions for insulin-dependent diabetes.

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Donor Information

  • Product Name
  • CellRapeutics™ CD3+ T Cells from Type 1 Diabetes Donor
  • Cat. No.
  • XS-0426-XU222
  • Donor Age
  • Young Adult
  • Donor Health
  • T cells are distinguished by the presence of autoreactive clones specific to pancreatic beta-cell antigens, reflecting a state of chronic cellular-mediated autoimmunity and specific HLA-linked immune signatures.
  • Ethnicity
  • Diverse backgrounds available, predominantly Caucasian.
  • Anticoagulant
  • Acid Citrate Dextrose, optimized to maintain precise pH levels, protecting autoreactive T-cell clones from acidotic stress and preserving their specific TCR-peptide binding affinity.
  • Additional Donor Information
  • Each lot features CD3+ T cells from T1DM donors. Profiles highlight the presence of islet-antigen reactive T cells and HLA-type information for autoimmune mechanism studies.
  • Clinical Profile
  • History of ketoacidosis episodes, C-peptide levels, and insulin pump or injection usage.

Additional Information

  • Medication History
  • Available upon request. Documentation of insulin therapy and history of immunotherapies aimed at modulating auto-reactive T-cell responses.
  • Formulation
  • Cryopreserved in specialized freezing medium
  • Cell Purity
  • >90%
  • Cell Viability
  • >90%
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • Negative
  • Genetic Stability Testing
  • The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.
  • Application
  • Drug Discovery, Immuno-oncology Research
  • Research Use Only
  • RUO
  • Quality Control
  • Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.
  • Storage
  • Store in liquid nitrogen vapor phase for long-term stability, maintain constant temperatures below -150°C to prevent loss of viability.
  • Shiping
  • Dry Ice
  • Handling Notes
  • Perform rapid thawing in a 37°C water bath and dilute slowly with pre-warmed media to ensure optimal cell recovery and function.
  • Warnings
  • Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.
  • Size
  • 2.5E7 cells/vial, 5E7 cells/vial
  • Keywords
  • CellRapeutics™ CD3+ T Cells from Type 1 Diabetes Donor, CD3+ T Cells, Type 1 Diabetes

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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