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CellRapeutics™ CD56+ NK Cells from Multiple Sclerosis Donor (XS-0426-XU297)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Sourced from donors with Multiple Sclerosis, these CD56+ NK cells are key to understanding the regulatory versus effector roles of the innate system in neuro-autoimmunity. These cells are isolated via negative selection to maintain their native activation state, facilitating the study of NK cell-mediated lysis of autoreactive T cells. Researchers utilize this product to explore the "bright" versus "dim" subset distribution and how these ratios influence the stability of the central nervous system.

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Donor Information

  • Product Name
  • CellRapeutics™ CD56+ NK Cells from Multiple Sclerosis Donor
  • Cat. No.
  • XS-0426-XU297
  • Donor Age
  • Young Adult
  • Donor Health
  • NK cells are characterized by a neuro-inflammatory regulatory profile. These cells show specific alterations in cytotoxic potential and subset distribution that reflect their role in modulating central nervous system targeted autoimmune responses.
  • Ethnicity
  • Diverse backgrounds available, predominantly Caucasian.
  • Anticoagulant
  • Heparin or Acid Citrate Dextrose, specifically adjusted to protect NK cell blood-brain barrier migration markers and maintain functional homeostasis against neuroinflammatory backgrounds.
  • Additional Donor Information
  • Each lot features CD56+ NK cells from donors with MS. Profiles include disease subtype and treatment history, enabling the study of NK cell-mediated regulation of autoreactive T cells.
  • Clinical Profile
  • MS phenotype, EDSS score, history of interferon or monoclonal antibody treatment, and time since last acute episode.

Additional Information

  • Medication History
  • Available upon request. Records of DMTs, focusing on agents that influence lymphocyte trafficking or systemic inflammation, potentially impacting NK cell surveillance.
  • Formulation
  • Cryopreserved in specialized freezing medium
  • Cell Purity
  • >90%
  • Cell Viability
  • >90%
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • Negative
  • Genetic Stability Testing
  • The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.
  • Application
  • Drug Discovery, Immuno-oncology Research
  • Research Use Only
  • RUO
  • Quality Control
  • Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.
  • Storage
  • Maintain long-term storage in liquid nitrogen vapor phase (below -150°C), avoid temperature fluctuations above -135°C to preserve NK cell lytic activity.
  • Shiping
  • Dry Ice
  • Handling Notes
  • Perform rapid thawing at 37°C and implement slow, dropwise dilution with pre-warmed media to minimize osmotic stress and ensure optimal cell recovery.
  • Warnings
  • Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.
  • Size
  • 5E6 cells/vial, 1E7 cells/vial
  • Keywords
  • CellRapeutics™ CD56+ NK Cells from Multiple Sclerosis Donor, CD56+ NK Cells, Multiple Sclerosis

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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