CellRapeutics™ Leukopak from Sickle Cell Trait Donor (XS-0426-XU263)

Name: CellRapeutics™ Leukopak from Sickle Cell Trait Donor
SKU: XS-0426-XU263
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This Leukopak is derived from donors heterozygous for the hemoglobin S mutation. While these donors are typically asymptomatic, their leucocytes reflect a unique physiological environment conditioned by intermittent rheological stress and altered vascular adhesion dynamics. This collection is particularly valuable for researchers investigating the protective mechanisms against malaria or the subtle, chronic pro-inflammatory signatures that differentiate the sickle cell carrier state from the healthy wild-type genotype.

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Donor Information

Product Name
CellRapeutics™ Leukopak from Sickle Cell Trait Donor

Cat. No.
XS-0426-XU263

Donor Age
Young Adult, Middle-Aged

Donor Health
Confirmed heterozygous carriers of the HbS gene. Leukocytes reflect a generally balanced immune state but may exhibit subtle metabolic adaptations and specific adhesion molecule expressions related to hemoglobin variant presence.

Ethnicity
Primarily African, Mediterranean, and Middle Eastern backgrounds.

Anticoagulant
Acid Citrate Dextrose, optimized to prevent erythrocyte sickling during processing and maximize leukocyte purity.

Additional Donor Information
Each lot features a Leukopak from donors with confirmed HbAS genotype. These samples provide a critical resource for studying cellular resilience and immune responses in individuals carrying the sickle cell gene.

Clinical Profile
Confirmed HbAS genotype via hemoglobin electrophoresis, baseline hemoglobin levels, and absence of prior vaso-occlusive crises.

Additional Information

Medication History
Available upon request. Documentation confirming the absence of sickle cell disease treatments and records of any iron supplementation or antimalarial prophylaxis.

Formulation
Cryopreserved or Fresh options available.

Cell Purity
>90%

Cell Viability
>90%

Mycoplasma Testing
Negative

Sterility Testing
Negative

Genetic Stability Testing
The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.

Application
Drug Discovery, Immuno-oncology Research

Research Use Only
RUO

Quality Control
Each product batch is strictly validated for high cellular viability, specific immune cell counts, and pathogen-free safety, ensuring consistent clinical phenotypes and ethical compliance for advanced immunological research.

Storage
Store fresh Leukopaks at 2°C to 8°C for immediate use, cryopreserved samples must be kept in liquid nitrogen vapor phase below -150°C.

Shiping
Dry Ice

Handling Notes
Process fresh cells within 48 hours or perform rapid thawing of cryovials in a 37°C water bath followed by gradual dilution to maximize recovery.

Warnings
Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.

Size
Full Bag, Half Bag

Keywords
CellRapeutics™ Leukopak from Sickle Cell Trait Donor, Leukopak, Sickle Cell Trait

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.