The vector of anti-CLL-1 chimeric antigen receptor (CAR) is based on the FcεRI receptor scaffold and constructed for the engineering of T cells to target human CLL-1. The T cells are genetically modified through transduction with a lentiviral vector expressing an alpha chain comprising a scFv of anti-CLL-1 antibody linked to FcεR1γ-SP and FcεR1γ-TM-IC, a beta chain comprising FcεR1γ-ΔITAM linked to CD28 signaling domain, a gamma chain comprising FcεR1γ-SP-ΔITAM linked to CD3ζ signaling domain. And the vector product was designed for the treatment of acute lymphoblastic leukemia.
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