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Human CD123 CAR Detection Reagent, His Tag (PE) (XS-0423-LX12)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Human CD123 CAR Detection Reagent, His Tag (PE) is applied for evaluating Human IL3RA CAR expression, and is suitable for FC application.

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Specifications

  • Target
  • CD123
  • Organism
  • Human
  • Application
  • Used for evaluating CAR expression
  • Purity
  • >90%
  • Endotoxin Level
  • Less than 1.0 EU per μg by the LAL method.
  • Storage
  • For long term storage, the product should be stored at lyophilized state at -20°C or lower.
    Please protect from light and avoid repeated freeze-thaw cycles.
  • Shelf-Life
  • Stable as supplied until expiry date on label.
  • Application Notes
  • The optimal working dilutions should be determined by the end user.
  • Diseases
  • Acute lymphoblastic leukemia (ALL)
  • Molecular Characterization
  • The CAR detection reagent contains AA Thr 19 - Arg 305 of Human IL3RA.
  • Conjugation
  • PE
  • Size
  • 25 tests; 100 tests
  • Formulation
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
  • Expression
  • HEK293 cell
  • Host Species
  • Human
  • Species Reactivity
  • Human
  • Form
  • Lyophilized

Target

  • Target Introduction
  • The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GMCSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a XY pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.
  • Target Alternative Names
  • interleukin 3 receptor subunit alpha
  • Entrez Gene ID
  • 3562

Related Resources

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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