Human CD30 CAR Detection Reagent, Fc Tag (CARD-LX046)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Evaluating CAR expression is an essential step in the production of CAR-T cells. Creative biolabs provides several detection reagents which are uniquely suitable for evaluation of CAR expression. Human CD30 CAR Detection Reagent, Fc Tag is a special detection reagent which carries a human IgG1 Fc tag at the C-terminus, and is used to detect human CD30 CAR related to the study of Leukemia, B-Cell lymphoma.

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Specifications

Target
CD30

Application
ELISA, FC

Purity
>90%

Endotoxin Level
Less than 1.0 EU per μg by the LAL method.

Storage
For long term storage, the product should be stored at lyophilized state at -56°C or lower.
Please avoid repeated freeze-thaw cycles.

Application Notes
The optimal working dilutions should be determined by the end user.

Diseases
Leukemia, B-Cell lymphoma

Molecular Characterization
It contains AA Phe 19 - Lys 379 (Accession # NP_001234.2).

Conjugation
Unconjugated

Tag
Fc Tag

Size
0.1 mg

Formulation
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

Expression
Human HEK293 cells

Host Species
Human

Species Reactivity
Human

Form
Lyophilized

Images
Figure 1 Structure

Target

Target Introduction
Human CD30 is also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. TNFRSF-8 is expressed by activated, but not by resting, T and B cells. Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15. CD30 is the receptor for TNFSF8/CD30L. CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B. TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

Target Alternative Names
TNF receptor superfamily member 8

Entrez Gene ID
943

UniProt ID
NP_001234.2

Related Resources

Overview of CD30-Targeted CAR Cell Therapies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Human CD30 CAR Detection Reagent, Fc Tag (CARD-LX046)

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Specifications

Target

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