Anti-MART-1 T cell receptor (S5-4), pCDTCR1(TCR-L127)

The vector of anti-MART-1 T cell receptor (TCR) is constructed for the engineering of T cell to target Human MART-1. The T cells are genetically modified through transduction with a lentiviral vector expressing MART-1-specific T cell receptor. And the vector product was designed for the treatment of Melanoma.


Details


Target
MART-1
Target Species
Human
Epitope
ELAGIGILTV
Format
Non-modified
HLA
HLA-A2
Targeting Diseases
Melanoma
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
S5-4
Antibody Host
Human

Target


Gene Name
MLANA
Official Symbol
MLANA
Gene ID
UniProt ID
Synonyms
DMF5; MLANA; MART1; MART-1; metastatic melanoma; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; Melan-A
Introduction
Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Carcinoma

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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