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Anti-Nef (RPMTYKGAL) T cell receptor, pCDTCR1 (TCR-C170Z)

The vector of anti-Nef T cell receptor (TCR) is constructed for the engineering of T cell to target HIV-1 Nef. The T cells are genetically modified through transduction with a lentiviral vector expressing Nef-specific T cell receptor. And the vector product was designed for the treatment of HIV-1 infection.

Details

  • Target
  • Nef
  • Target Species
  • HIV-1
  • Epitope
  • RPMTYKGAL
  • Format
  • Non-modified
  • HLA
  • HLA-B0702
  • Targeting Diseases
  • HIV-1 infection
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Host
  • Human

Target

  • Gene Name
  • Nef
  • Official Symbol
  • Nef
  • Synonyms
  • HIV Nef; Human Immunodeficiency Viruse Nef; Human Immunodeficiency Viruse; HIV Nef protein; HIV Nef-protein
  • Introduction
  • The HIV Nef protein is a multifunctional virulence factor that perturbs intracellular membranes and signalling and is secreted into exosomes. While Nef-containing exosomes have a distinct proteomic profile, no comprehensive analysis of their miRNA cargo has been carried out. Since Nef functions as a viral suppressor of RNA interference and disturbs the distribution of RNA-induced silencing complex proteins between cells and exosomes, we hypothesized that it might also affect the export of miRNAs into exosomes.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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