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Anti-pp65 T cell receptor (Codon optimized), pCDTCR1 (TCR-C218Z)

The vector of anti-pp65 T cell receptor (TCR) is constructed for the engineering of T cell to target CMV pp65. The T cells are genetically modified through transduction with a lentiviral vector expressing pp65-specific T cell receptor. And the vector product was designed for the treatment of Cytomegalovirus infection.

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Details

  • Target
  • pp65
  • Target Species
  • CMV
  • Epitope
  • NLVPMVATV
  • Format
  • Codon optimized
  • HLA
  • HLA-A2.1
  • Targeting Diseases
  • Cytomegalovirus infection
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Host
  • Human

Target

  • Official Symbol
  • pp65
  • Introduction
  • Cytomegalovirus (CMV) is a member of the herpes virus group which includes herpes simplex virus types 1 and 2; Varicella Zoster Virus, which causes chicken pox; and Epstein Barr virus, which causes infectious mononucleosis. These viruses remain dormant within the body over a long period. In humans, CMV is known as HCMV or human herpesvirus 5 (HHV-5). HHV-5 causes only a brief mononeucleosis-like malaise in immunocompetent adults, but may cause severe illness or death in immunosuppressed individuals. CMV pp65 is the early-late lower matrix phosphoprotein of CMV that may be relevant to the etiopathogenesis of scleroderma. CMV pp65 is a major constituent of the CMV virion bodies and is abundantly synthesized during lytic infection. In addition, the CMV pp65 protein is a frequent target for the exceptionally strong CMV-specific CD8(+) T cell response.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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