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Anti-Titin T cell receptor (MAG-IC3), pCDTCR1 (TCR-C251Z)

The vector of anti-Titin T cell receptor (TCR) is constructed for the engineering of T cell to target Human Titin. The T cells are genetically modified through transduction with a lentiviral vector expressing Titin-specific T cell receptor. And the vector product was designed for the treatment of Autoimmune Diseases.

Details

  • Target
  • Titin
  • Target Species
  • Human
  • Epitope
  • ESDPIVAQY
  • Format
  • Non-modified
  • HLA
  • HLA-A1
  • Targeting Diseases
  • Autoimmune Diseases
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Clone
  • MAG-IC3
  • Antibody Host
  • Human

Target

  • Gene Name
  • Titin
  • Official Symbol
  • TIN
  • Synonyms
  • TIN; Titin; TMD; CMH9; CMD1G; CMPD4; EOMFC; HMERF; MYLK5; LGMD2J
  • Introduction
  • This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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