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K-NK: Inhibitory KIR (iKIR) Knockout NK Cell Engineering Service

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Natural killer (NK) cell education requires ligands to bind to inhibitory NK cell receptor (iNKR), which is very important for producing self-tolerant functional NK cells. The main family of inhibitory NK cell receptors is inhibitory KIRs (iKIRs), which interact with their HLA class I ligands to play an important role in NK cell regulation and protect normal tissues from NK cell attack. To enhance the anti-tumor efficacy of NK cells, we optimized these unique activated NK cells, which lack KIR inhibitory receptors while retaining a wide range of activated receptors that enable selectively target and kill tumor cells.

Our Unique K-NK Platform

The panoply of activating and inhibiting receptors on NK cells and the myriad mechanisms by which NK cells mediate cytotoxicity provide ample opportunities to engineer NK cells using genetic methods aimed at making signal balance tend to be activated. Our unique NK cell platform has been produced and used as a cell-based "off the shelf" therapy in clinical trials and has proven its potential to kill cancer.

Unlike normal NK cells, our unique K-NK cells do not express iKIRs, which are often used by diseased cells to escape the killing function of NK cells. These unique activated NK cells are optimized to retain a wide range of activated receptors while lacking KIR inhibitory receptors, which can selectively target and kill diseased cells. K-NK cells also carry larger granzymes and perforin-containing particles, allowing them to provide a larger payload of lethal enzymes to multiple targets. Encouraging evidence of safety, mobility and prolonged survival have been proven.

NK cell engineering strategies to enhance NK cell cytotoxicity against tumors.

Fig.1 NK cell engineering strategies to enhance NK cell cytotoxicity against tumors.

Features of Our K-NK Platform

Off-the-Shelf

A universal cell-based therapy that does not require personalized patient matching.

Eliminate a Step

No need to collect the patient’s white blood cells. With off-the-shelf aNK, this invasive procedure is eliminated.

Dosing Control

K-NK’s clearance and multiple dosing may reduce the risk of adverse events, thereby producing a favorable safety profile.

Cost Effective

Economical cell therapy treatment for cancer patients aNK can be produced in large multi-dose batches.

One-Stop CAR-NK Therapy Development

Notably, as the leading cell therapeutics biotech that provides cell therapy related services, Creative Biolabs provides one-stop services for CAR-NK therapy development, including but not limited to:

If you are interested in our services, please send an email to contact us, and our team will get back to you as soon as possible.

Reference

  1. Daher, M., & Rezvani, K. (2018). Next generation natural killer cells for cancer immunotherapy: the promise of genetic engineering. Current opinion in immunology, 51, 146-153.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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