Lenti-B7H6 CAR (scFv-28εRIγ, 47.39)-VP(VP-CAR-LC16)
The ready-to-use lentiviral particles of Lenti-B7H6 CAR (scFv-28εRIγ, 47.39)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (47.39)-CD28-FcεRIγ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.
Specifications
Type of Therapeutics
Chimeric Antigen Receptor
Expression Cassette
scFv (47.39)-CD28-FcεRIγ
Packaging System
Lentivirus
Targeting Diseases
Chronic lymphoid leukemia ( CLL )
Target
Introduction
B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
Alternative Names
B7H6; B7-H6; DKFZp686O24166; CD28; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; scFv; 47.39
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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Leukemia
Datasheet
