Lenti-CD20 CAR (scFv-CD4εRIγ, 1F5)-VP(VP-CAR-LC346)
The ready-to-use lentiviral particles of Lenti-CD20 CAR (scFv-CD4εRIγ, 1F5)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (1F5)-CD4-FcεRIγ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.
Specifications
Type of Therapeutics
Chimeric Antigen Receptor
Expression Cassette
scFv (1F5)-CD4-FcεRIγ
Packaging System
Lentivirus
Targeting Diseases
CD20+ malignancies; B-cell lymphoma; mantle cell lymphoma; CD20+ diffuse large cell lymphoma (DLCL); leukemias
Target
Introduction
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; Chronic lymphocytic leukemia; CLL; leukemia; scFv; FcεRIγ; Chimeric antigen receptor; NK cell; Retrovirus; CARs; Lentivirus; chimeric NK cell receptors; chimeric immunoreceptors; chimeric antigen receptors; rituximab
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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LeukemiaOthersAutoimmune Diseases
Datasheet
