Lenti-CD30 CAR (scFv-εRIγ, BerH2)-VP(VP-CAR-LC486)
The ready-to-use lentiviral particles of Lenti- CD30 CAR (scFv-εRIγ, BerH2)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (BerH2)-FcεRIγ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.
Specifications
Type of Therapeutics
Chimeric Antigen Receptor
Expression Cassette
scFv (BerH2)-FcεRIγ
Packaging System
Lentivirus
Targeting Diseases
Hodgkin lymphoma (HL)
Target
Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alternative Names
CD30; Ki-1; D1S166E
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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Lymphoma
Kits for CARs/TCRs Development 
Datasheet
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