Lenti-CD87 CAR (scFv-BBζ-IL12)-VP(VP-CAR-LC734)

The ready-to-use lentiviral particles of Lenti-CD87 CAR (scFv-BBζ-IL12)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv-41BB-CD3ζ-IL12 packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
CD87
Expression Cassette
scFv-41BB-CD3ζ-IL12
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Small-cell lung cancer, Ovarian cancer

Target


Introduction
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
Alternative Names
PLAUR; plasminogen activator, urokinase receptor; CD87; UPAR; URKR; U-PAR
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products


Carcinoma

Online Inquiry

Name:
* Phone:
*E-mail Address:
*Service & Products Interested:
Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.
CB Promise
CONTACT US
45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-871-5806
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON