1. Home
  2. HLA-A2
  3. Lenti-HLA-A2 CAR (scFv-CD3ζ, BB7.2) Viral Particle

Lenti-HLA-A2 CAR (scFv-ζ, BB7.2)-VP(VP-CAR-LC808)

DatasheetDatasheet

Online Inquiry

The ready-to-use lentiviral particles of Lenti-HLA-A2 CAR (scFv-ζ, BB7.2)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (BB7.2)-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

Type of Therapeutics
Chimeric Antigen Receptor
Target
HLA-A2
Expression Cassette
scFv (BB7.2)-CD3ζ
Clone
BB7.2
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Allograft rejection and Graft-versus-host disease (GVHD)

Target

Introduction
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
Alternative Names
HLAA
Gene ID
3105

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Cat# Description
VP-CAR-LC810 Lenti-HLA-A2 CAR (scFv-41BB-CD3ζ, BB7.2) Viral Particle
CAR-MZ123 Anti-HLA-A2/WT1Db126 (F2) h(CD28- FcγRIγ) CAR, pCDCAR1
CAR-MZ111 Anti-HLA-A2 (BB7.2) h(41BB-CD3ζ) CAR, pCDCAR1
VP-CAR-LC823 Lenti-HLA-A2-WT1Db126 CAR (scFv-FcγRIγ, F3) Viral Particle
CAR-MZ110 Anti-HLA-A2 (BB7.2) h(CD28-CD3ζ) CAR, pCDCAR1
CAR-MZ109 Anti-HLA-A2 (BB7.2) h(CD3ζ) CAR, pCDCAR1
VP-CAR-LC822 Lenti-HLA-A2-WT1Db126 CAR (scFv-FcγRIγ, F2) Viral Particle
CAR-MZ124 Anti-HLA-A2/WT1Db126 (F3) h(CD28- FcγRIγ) CAR, pCDCAR1
VP-CAR-LC809 Lenti-HLA-A2 CAR (scFv-CD28-CD3ζ, BB7.2) Viral Particle

Others Kits for CARs/TCRs Development 

Online Inquiry

Name:
* Phone:
*E-mail Address:
*Service & Products Interested:
Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.
CB Promise
CONTACT US
45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

To view the contact information for a specific location, select your country or region:

Australia
australia

FOLLOW US ON

Copyright © 2007 - 2018 Creative Biolabs. All Rights Reserved