Lenti-ROR1 CAR (scFv-28, 2A2)-VP(VP-CAR-LC425)

The ready-to-use lentiviral particles of Lenti-ROR1 CAR (scFv-28, 2A2)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (2A2)-CD28 packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
ROR1
Expression Cassette
scFv (2A2)-CD28
Clone
2A2
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
B cell-chronic lymphocytic leukemia (B-CLL); MCL tumor

Target


Introduction
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Alternative Names
ROR1; receptor tyrosine kinase-like orphan receptor 1; NTRKR1; dJ537F10.1; pre-B acute lymphoblastic leukemia;acute lymphoblastic leukemia; B cell-chronic lymphocytic leukemia; B-CLL; MCL tumor; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; 2A2
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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LeukemiaOthers

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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